Margareta Suber was born in Linköping, where her father was a doctor. She graduated from university in 1915, worked from 1916 to 1924 as a journalist, and made her debut in 1932 with her novel Charlie about a modern tomboy with homosexual leanings.
Her psychological, deeply penetrating modern-day novels with themes such as women's problems and marital problems – for example Ett helsike för en man, 1933, Du står mig emot, 1939, Jonna, 1940, Alla bära de svärd, 1947, Äkta paret ut, 1958, and Leva på italienska, 1976, demonstrate a developed sense of style and an intuitive understanding of irrational and problematic mental states. She made her debut as a poet at the age of eighty-six in 1978 with her work Allt som närmar sig followed by Böljegång, 1980. She is also known as a travel writer and translator and has also written children's books under the name Margareta Topelius.